Here's my attempt at a 180 card cube (seems pretty broken).
180 TOTAL CARDS (45x4)
100 COLORED cards (20 each), 10 spells, 10 creatures (15/5 for blue, 5/15 for green)
30 ARTIFACTS
30 LANDS
20 MULTI-COLORED (2 for each bi color)
BLUE:
15 Blue Spells:
1 Ancestral Recall
1 Brainstorm
1 Fact or Fiction
1 Gifts Ungiven
1 Merchant Scroll
1 Thirst for Knowledge
1 Time Walk
1 Tinker
1 Mystical Tutor
1 Exclude
1 Jace, Mind Sculptor
1 Mana Drain
1 Treachery
1 Control Magic
1 Cryptic Command
5 Blue Creatures
1 Meloku the Clouded Mirror
1 Vesuvan Doppleganger
1 Vesuvan Shapeshifter
1 Tradewind Rider
1 Sower of Temptation
BLACK:
10 Black Spells
1 Sorin Markov
1 Liliana Vess
1 Demonic Tutor
1 Skeletal Scrying
1 The Abyss
1 Vampiric Tutor
1 Yawgmoth's Will
1 Cabal Ritual
1 Dark Ritual
1 Tendrils of Agony
10 Black Creatures
(3) 1-2 CMC
1 Dark Confidant
1 Nantuko Shade
1 Cabal Interrogator
(4) 3-4 CMC
1 Hypnotic Specter
1 Juzám Djinn
1 Nekrataal
1 Abyssal Persecutor
(3) 5+ CMC
1 Kokusho, the Evening Star
1 Shriekmaw
1 Skeletal Vampire
RED:
10 Red Spells
1 Wheel of Fortune
1 Hammer of Bogardan
1 Staggershock
1 Browbeat
1 Fork
1 Rolling Earthquake
1 Banefire
1 Firebolt
1 Chandra Nalaar
1 Wildfire
10 Red Creatures
(3) 1-2 CMC
1 Grim Lavamancer
1 Magus of the Scroll
1 Hellspark Elemental
(4) 3-4 CMC
1 Jaya Ballard, Task Mage
1 Brimstone Mage
1 Avalanche Riders
1 Flametongue Kavu
(3) 5+ CMC
1 Arc-Slogger
1 Kumano, Master Yamabushi
1 Flameblast Dragon
GREEN:
5 Green Spells:
1 Regrowth
1 Sylvan Library
1 Garruk Wildspeaker
1 Berserk
1 Hurricane
15 Green Creatures:
(5) 1-2 CMC
1 Scute Mob
1 Birds of Paradise
1 Noble Heirarch
1 Tarmogoyf
1 Lotus Cobra
(5) 3-4 CMC
1 Eternal Witness
1 Caller of the Claw
1 Wickerbough Elder
1 Uktabi Orangutan
1 Master of the Wild Hunt
(5) 5+ CMC
1 Spectral Force
1 Mycoloth
1 Deranged Hermit
1 Kodama of the North Tree
1 Rampaging Baloths
WHITE:
10 White Spells
1 Balance
1 Armageddon
1 Wrath of God
1 Akroma's Vengeance
1 Land Tax
1 Gideon Jura
1 Elspeth, Knight-Errant
1 Ajani Goldmane
1 Swords to Plowshares
1 Oblivion Ring
10 White Creatures:
(4) 1-2 CMC
1 Mother of Runes
1 Eight-and-a-Half-Tails
1 Soltari Priest
1 Soltari Monk
(3) 3-4 CMC
1 Emeria Angel
1 Wall of Reverence
1 Paladin En-Vec
(3) 5+ CMC
1 Baneslayer Angel
1 Pristine Angel
1 Akroma, Angel of Wrath
30 Artifacts
10 Mana Artifacts
1 Mox Sapphire
1 Mox Jet
1 Mox Ruby
1 Mox Emerald
1 Mox Pearl
1 Black Lotus
1 Sol Ring
1 Coalition Relic
1 Darksteel Ingot
1 Spectral Searchlight
15 Non-Creature, Non-Mana Artifacts
1 Chaos Orb
1 Nevinyrral's Disk
1 Oblivion Stone
1 Sensei's Divining Top
1 Scroll Rack
1 Cursed Scroll
1 Umezawa's Jitte
1 Skullclamp
1 Sword of Fire and Ice
1 Loxodon Warhammer
1 Mindslaver
1 Crucible of Worlds
1 Icy Manipulator
1 Crystal Shard
1 Isochron Scepter
5 Artifact Creatures
1 Masticore
1 Razormane Masticore
1 Duplicant
1 Solemn Simulacrum
1 Sundering Titan
30 Lands
10 Dual Lands
10 Fetch Lands
10 Ravnica Bounce Lands
20 Multicolored Cards:
2 of each BI-COLOR:
UB
1 Oona, Queen of the Fae
1 Shadowmage Infiltrator
UR
1 Fire/Ice
1 Prophetic Bolt
UG
1 Mystic Snake
1 Lorescale Coatl
UW
1 Teferi's Moat
1 Azorius Guildmage
BR
1 Sarkhan the Mad
1 Terminate
BG
1 Maelstrom Pulse
1 Pernicious Deed
BW
1 Vindicate
1 Mortify
RG
1 Sarkhan Vol
1 Stormbind
RW
1 Ajani Vengeant
1 Figure of Destiny
GW
1 Loxodon Heirarch
1 Qasali Pridemage